5hzb

Crystal structure of GII.10 P domain in complex with 2-fucosyllactose (2'FL)

spinqualitylabelsall models 5hzb, resolution 1.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5hzb is a 2 chain structure with sequence from Norovirus GII.10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.553Å Ligands: EDO, FUC, GAL, GLC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5F4T5_9CALI Publication Abstract from PubMed Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2' -fucosyllactose (2' FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2' FL and 3FL bound at the equivalent HBGA pocket on the norovirus capsid using X-ray crystallography. Our data revealed that 2' FL and 3FL structurally mimic HBGAs. These results suggest that 2' FL and 3FL might act as natural-occurring decoys in humans. Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.,Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS J Virol. 2016 Feb 17. pii: JVI.03223-15. PMID:26889023 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus coat proteins 3D structures

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