6bst

CRYSTAL STRUCTURE OF Z-DNA WITH UNTYPICALLY COORDINATED CA2+ ION

spinqualitylabelsall models 6bst, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bst is a 2 chain structure with sequence from Synthetic construct. This structure supersedes the now removed PDB entry 6b01. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.45Å Ligands: CA, SR0 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed DNA oligomer duplexes with alternating cytosines and guanines in their sequence tend to form helices of the Z-DNA type, where the sugar and phosphate backbone forms a left-handed helix in a zigzag fashion with a repeat of two successive Watson-Crick pairs of nucleotides. Z-DNA duplexes often crystallize in complexes with diverse metal ions interacting with polar DNA atoms in various ways. This work describes the high-resolution crystal structure of a Z-DNA d(CGCGCG)2 duplex in complex with Ca(2+) ions, unusually coordinated as an approximate pentagonal bipyramid by two neighboring guanines through their O6 and N7 atoms and a water molecule in the equatorial plane and a phosphate oxygen atom and another water molecule in the apical positions. The crystal structure of Z-DNA with untypically coordinated Ca(2+) ions.,Luo Z, Dauter Z J Biol Inorg Chem. 2017 Dec 21. pii: 10.1007/s00775-017-1526-4. doi:, 10.1007/s00775-017-1526-4. PMID:29270817 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Z-DNA

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