Structural highlights
6nie is a 4 chain structure with sequence from Streptomyces cattleya NRRL 8057 = DSM 46488. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.95Å |
| Ligands: | AKG, CL, FE, FE2, LYS |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
BESD_STREN Involved in the biosynthesis of terminal alkyne-containing amino acids produced as antibiotics by S.cattleya. Catalyzes the chlorination of L-lysine at the C4 position, leading to the production of 4-chloro-L-lysine.[1]
References
- ↑ Marchand JA, Neugebauer ME, Ing MC, Lin CI, Pelton JG, Chang MCY. Discovery of a pathway for terminal-alkyne amino acid biosynthesis. Nature. 2019 Mar;567(7748):420-424. doi: 10.1038/s41586-019-1020-y. Epub 2019 Mar, 13. PMID:30867596 doi:https://dx.doi.org/10.1038/s41586-019-1020-y
