7rom

Crystal structure of Saccharomyces cerevisiae NADH-cytochrome b5 reductase 1 (Cbr1) fragment (residues 28-284) bound to FAD

spinqualitylabelsall models 7rom, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7rom is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.65Å Ligands: CL, FAD, PGE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function NCB5R_YEAST NADH-dependent reductase for KTI11/DPH3 and cytochrome b5 (PubMed:14930, PubMed:10622712, PubMed:27694803, PubMed:31463593, PubMed:34154323). Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:31463593, PubMed:34154323, PubMed:27694803). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:31463593, PubMed:34154323). By reducing KTI11/DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex (PubMed:27694803). The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (PubMed:10622712). Plays a role in bud morphology (PubMed:17895367). See Also NADH-cytochrome b5 reductase

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