7sl8

CryoEM structure of SGLT1 at 3.4 A resolution

spinqualitylabelsall models 7sl8, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7sl8 is a 2 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.4Å Ligands: CLR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Glucose is a primary energy source in living cells. The discovery in 1960s that a sodium gradient powers the active uptake of glucose in the intestine(1) heralded the concept of a secondary active transporter that can catalyse the movement of a substrate against an electrochemical gradient by harnessing energy from another coupled substrate. Subsequently, coupled Na(+)/glucose transport was found to be mediated by sodium-glucose cotransporters(2,3) (SGLTs). SGLTs are responsible for active glucose and galactose absorption in the intestine and for glucose reabsorption in the kidney(4), and are targeted by multiple drugs to treat diabetes(5). Several members within the SGLT family transport key metabolites other than glucose(2). Here we report cryo-electron microscopy structures of the prototypic human SGLT1 and a related monocarboxylate transporter SMCT1 from the same family. The structures, together with molecular dynamics simulations and functional studies, define the architecture of SGLTs, uncover the mechanism of substrate binding and selectivity, and shed light on water permeability of SGLT1. These results provide insights into the multifaceted functions of SGLTs. Structure and mechanism of the SGLT family of glucose transporters.,Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L Nature. 2022 Jan;601(7892):274-279. doi: 10.1038/s41586-021-04211-w. Epub 2021 , Dec 8. PMID:34880492 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Sodium/glucose cotransporter 3D structures Symporter 3D structures

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