9hpr

Variant K314A of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with 6-Methyl UMP at 1.1 Angstrom resolution

spinqualitylabelsall models 9hpr, resolution 1.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9hpr is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.1Å Ligands: CSS, PRO, U6M Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease UMPS_HUMAN Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. Function UMPS_HUMAN

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