9qqs

Structure of the MEGF8-MOSMO complex with nanobody 270 (Focused refinement)

spinqualitylabelsall models 9qqs, resolution 2.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9qqs is a 3 chain structure with sequence from Homo sapiens and Lama glama. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.65Å Ligands: A1JAX, PLM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MOSMO_HUMAN Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation.[UniProtKB:Q8C784]

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