A-kinase anchor protein

spinqualitylabelsall models Human AKAP18 helix (deepskyblue) complex with a dimer of cAMP-dependent protein kinase regulatory subunit (magenta and green) and Cd+2 ions (PDB code 4zp3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function A-kinase anchor proteins (AKAP) mediate the localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes by interacting with them . AKAPs form multi-protein complexes via interaction with the regulatory subunits of PKA. These protein complexes are key molecules in the biochemical machinery regulating the function of flagella and cilia. A-kinase anchor protein 10 is also named dual specificity A-kinase anchor protein 2. Small membrane A-kinase anchor protein (smAKAP) is localised at the plasma membrane. Relevance AKAPs play a central role in organizing signaling pathways which control cardiac contractility and rhythm as well as the pathological response of the heart to stress and other dysfunctions such as arrhythmias, cardiac hypertrophy and heart failure. Structural highlights An ampiphatic helix of AKAP18 binds with its hydrophobic sides to helices of the PKA regulatory subunit. Hydrophobic, Polar 3D Structures of A-kinase anchor protein A-kinase anchor protein 3D structures

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