Phosphoribosylaminoimidazole carboxylase

spinqualitylabelsall models Structure of E. coli PurE octamer complex with 5-aminoimidazole ribonucleotide (AIR) (PDB entry 1d7a) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phosphoribosylaminoimidazole carboxylase (PurE) or N5-carboxyaminoimidazole ribonucleotide mutase is part of the purine biosynthesis and catalyzes the reversible conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 5-aminoimidazole ribonucleotide (AIR). In bacteria PurE and PurK or Phosphoribosylaminoimidazole carboxylase ATPase subunit are independent enzymes while in plants and fungi it is a domain of phosphoribosylaminoimidazole carboxylase. PurK catalyzes the conversion of AIR,ATP and bicarbonate to N5-CAIR, ADP and phosphate. Structural highlights The biological assembly of E. coli PurE is octamer. PurE active site is located in a cleft between 3 subunits. Water molecule is shown as red sphere. 3D structures of PurE Phosphoribosylaminoimidazole carboxylase 3D structures

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