Porphobilinogen synthase

spinqualitylabelsall models Yeast porphobilinogen synthase complex with laevulunic acid and Zn+2 ion (grey) (PDB entry 1h7n) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Porphobilinogen synthase or δ-aminolaevulinic acid dehydratase (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolaevulinic acid (ALA). PBS participates in porphyrin biosynthesis. Levulinic acid (LA) is an inhibitor of PBS. Porphyrin is the precursor of hemes, chlorophyll and vitamin B12. Disease PBS deficiency can be caused by lead and other heavy metal poisoning. Structural highlights The biological assembly of Yeast porphobilinogen synthase is homooctamer. The active site of PBS contains the substrate laevulinic acid and Zn+2 ion. Water molecules are shown as red spheres.

3D structures of porphobilinogen synthase

Updated on 06-October-2020

{"openlevels":0}

• Porphobilinogen synthase
  • 5hms, 5hnr – hPBS + Zn – human
    
  • 1pv8 – hPBS (mutant)
    
  • 2z0i, 2z1b - PBS - mouse
    
  • 1aw5 – yPBS (mutant) + Zn – yeast
    
  • 1qml - yPBS + Hg
    
  • 1qnv - yPBS + Pb
    
  • 1w54, 1w56, 1w5m, 1w5n, 1w5o, 1w5p, 1w5q - PaPBS (mutant) + Mg + Zn – Pseudomonas aeruginosa
    
  • 5lzl - PBS + Zn – Pyrobaculum calidifontis
    
• Porphobilinogen synthase complex
  • 1e51 - hPBS + PBG + Zn
    
  • 1ylv, 1h7n - yPBS + LA + Zn
    
  • 1w31 - yPBS + LA derivative + Zn
    
  • 1h7o - yPBS + ALA + Zn
    
  • 1h7r, 1h7p, 1eb3, 1gjp - yPBS + inhibitor + Zn
    
  • 1ohl - yPBS + intermediate + Zn
    
  • 1b4e - EcPBS + LA + Zn – Escherichia coli
    
  • 5mhb - EcPBS + PBG + Zn
    
  • 1i8j, 1l6s, 1l6y - EcPBS + inhibitor + Mg + Zn
    
  • 2c1h - PBS + inhibitor + Mg – Chlorobium vibrioforme
    
  • 2c13, 2c14 - PaPBS (mutant) + inhibitor + Mg
    
  • 2c15, 2c16, 2c18, 2c19 - PaPBS + inhibitor + Mg
    
  • 1b4k - PaPBS + LA + Zn
    
  • 1gzg - PaPBS + LA derivative + Mg
    
  • 2woq - PaPBS + antibiotic + Mg
    
  • 1w1z - PBS + LA + Mg – Prosthecochloris vibrioformis
    
  • 3obk - PBS residues 303-658 + Mg + PBG – Toxoplasma gondii
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman