ATPase family AAA domain-containing protein 2

spinqualitylabelsall models Human ATAD2A bromodomain comples with benzimidazol derivative inhibitor and Cl- ions (green) (PDB code 4tyl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function ATPase family AAA domain-containing protein 2 (ATAD2) catalyzes the addition of H2O to ATP to produce ADP and phosphate. ATAD2 may be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes. Relevance Overexpression of ATAD2 has been linked to breast cancer, hepatocellular carcinoma and lung adenocarcinoma. Structural highlights Benzimidazol derivative inhibitor binds within ATAD2A bromodomain ε-N-acetyllysine recognition site on histone proteins (Kac binding site) and interacts with the protein via hydrogen bond and hydrophobic interactions. Water molecules are shown as red spheres. 3D structures of ATPase family AAA domain-containing protein 2 ATPase family AAA domain-containing protein

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