Acetyl-CoA synthetase

spinqualitylabelsall models Acetyl-CoA synthetase complex with CoA and AMP (PDB code 2p2j) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Acetyl-CoA synthetase (ACS) catalyzes the ligation of acetate and CoA to form acetyl-CoA with the conversion of ATP to AMP and pyrophosphate. ACS is an ATP-dependent AMP-binding enzyme. Mg+2 is ACS cofactor. ACS participates in the pathway which fixes CO2 under anaerobic conditions. ACS acetylates the response regulator for flagellar movement and for chemotaxis - CheY. Relevance Acetyl-CoA is used in aerobic respiration to produce energy and electron carriers and for lipid biosynthesis, in histone acetylation which is critical for DNA condensation to chromatin. Structural Highlights CoA binding site. Water molecules shown as red spheres. AMP binding site. CoA/AMP binding site (2p2j). 3D structures of acetyl-CoA synthetase Acetyl-CoA synthetase 3D structures

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