Function
Adapter molecule crk (Crk) (CT10 Regulatior of Kinase) or p38 is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.[1] See also SRC and Oncogenes & Tumor Suppressor Genes.
Structural highlights
Crk domains include several N-terminal SH2 and C-terminal SH3 domains. Mouse Crk N terminal SH3 domain complex with proline-rich peptide (1cka)[2] is shown.
3D structures of adapter molecule crk
Adapter molecule crk 3D structures
- ↑ Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608
- ↑ Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 15;3(2):215-26. PMID:7735837
