Adenosine deaminase

spinqualitylabelsall models Structure of adenosine deaminase complex with Zn+2 (grey), acetonitrile and adenosine (stick figure) (PDB entry 2pgf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Adenosine deaminase (ADA) or double-stranded RNA-specific editase deaminates adenosine and deoxyadenosine into inosine or deoxyinosine. ADA is part of the purine metabolism. In humans ADA is involved in the development and maintenance of the immune system. ADA binds dipeptidyl peptidase IV. The complex acts as a positive regulator of T-cell coactivation and regulates lymphocytes-epithelial adhesion. Double-stranded RNA-specific adenosine deaminase catalyses the C-6 deamination of adenosine in viral RNAs and cellular pre-mRNA. tRNA-specific adenosine deaminase catalyses the deamination of adenosine to inosine in tRNA. Disease ADA deficiency is the cause of severe combined immunodeficiency (SCID). SCID was the first disorder to be treated by gene therapy. Relevance ADA is used in testing for the presence of tuberculosis as its level is increased in TB patients. Structural highlights There are 2 isoforms of ADA: ADA1 and ADA2. ADA contains Zn+2 ion in its active site (2pgf). Water mlecules are shown as red spheres. 3D Structures of adenosine deaminase Adenosine deaminase 3D structures

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