Adenosine kinase

spinqualitylabelsall models Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Adenosine kinase (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog. Disease AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy. Structural highlights AdK consists of a large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices (PDB entry 1bx4). 1st adenosine binding site. Water molecules are shown as red spheres. Cl coordination site. Cl/Mg cluster coordination site. 2nd adenosine binding site. 3D structures of adenosine kinase Adenosine kinase 3D structures

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