Adenylosuccinate lyase

spinqualitylabelsall models Adenylsuccinate lyase complex with AMP, oxalate, PEG 400 and Cl- ion (green) (PDB code 2x75) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Adenylosuccinate lyase (ASL) is a bifunctional enzyme acting in purine synthesis and purine nucleotide recycling. ASL caalyzes two reactions: the cleavage of adenylsuccinate to AMP and fumarate and the cleavage of phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) into 5-aminoimidazole-4-carboxamide (AICAR) and fumarate. Disease Mutations in ASL cause autosomal recessive disorder which manifests itself by encephalopathy with epilepsy and marked psychomotor retardation. Structural highlights The ASL can be divided into 3 domains. The active site is situated between the 3 domains and contains the product AMP and and oxalate. Water molecules are shown as red spheres. Oxalate binding. 3D structures of adenylosuccinate lyase Adenylosuccinate lyase 3D structures

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