Adrenergic receptor 3D structures

3D Structures of Adrenergic receptor

Updated on 01-December-2024

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• α-1 adrenergic receptor
  • 7b6w – hA1BAR + agonist - human
    
  • 7ymj – hA1AR + nanobody + tamsulosin – Cryo EM
    
  • 8hn1 – hA1AR + ADTX1 + nanobody – Cryo EM
    
  • 8thk, 8thl – hA1AR/endolysin + Guanine nucleotide binding protein + scFvy – Cryo EM
    
  • 7ym8 – hA1AAR + miniGSQ+ nanobody + oxymetazoline – Cryo EM
    
  • 7ymh – hA1AAR + miniGSQ+ nanobody + noradernaline – Cryo EM
    
• α-2 adrenergic receptor
  • 6kuy – hA2AR + partial agonist
    
  • 1ho9, 1hod – hA2AR peptide (mutant) – NMR
  • 1hof, 1hll - hA2AR peptide – NMR
  • 6kuw – hA2ACR + cholesterol + quinolone derivative
    
  • 6k41, 6k42 – hA2AAR/A2BAR + Gunine nucleotide binding protein + scFv – Cryo EM
    
  • 9cbm – hA2AR + Guanine nucleotide binding protein + drug – Cryo EM
    
  • 7w6p, 7w7e – hA2AR + Guanine nucleotide binding protein + scFv + agonist – Cryo EM
    
  • 7ym8 – hA2AR + Guanine nucleotide binding protein + scFv + agonist – Cryo EM
    
  • 9cbl – hA2AR/endolysin + Guanine nucleotide binding protein + adrenaline + epinephrine – Cryo EM
    
  • 7ej0, 7ej8, 7eja, 7ejk – hA2AR + Guanine nucleotide binding protein + scFv + drug – Cryo EM
    
  • 6kux – A2AR + antagonist – Spodoptera frugiperda
    
• β-1 adrenergic receptor
  • 7bts – hB1AR/T4 lysozyme (mutant) + nanobody + epinephrine
    
  • 7bu6, 7bu7 – hB1AR/endolysin + nanobody + epinephrine derivative
    
  • 8dcs – hB1AR/endolysin + nanobody + carbonitrile derivative
    
  • 7bvq – hB1AR/endolysin + carazolol
    
  • 2y01, 4gpo, 5f8u – tB1AR fragment (mutant) – turkey
    
  • 1dep – tB1AR peptide - NMR
    
  • 2y00, 2y02, 2y03, 2y04, 2vt4, 4ami, 4amj, 5a8e - tB1AR fragment (mutant) + agonist
    
  • 2ycw, 2ycx, 2ycz, 2ycy - tB1AR fragment (mutant) + antagonist
    
  • 3zpq, 3zpr - tB1AR fragment (mutant) + aryl piperazine inhibitor
    
  • 4bvn - tB1AR + cyanopindolol
    
  • 6h7j, 6h7l, 6h7m, 6h7n, 6h7o, 6ibl – tB1AR (mutant) + nanobody + thioredoxin + agonist
    
  • 7s0f, 7s0g - tB1AR + guanine nucleotide-binding protein + drug – Cryo EM
    
  • 7jjo - tB1AR + guanine nucleotide-binding protein + nanobody + drug – Cryo EM
    
  • 8dch - tB1AR/endolysin + guanine nucleotide-binding proteins + nanobody + drug – Cryo EM
    
  • 6tko - tB1AR + arrestin + antibody + modulator – Cryo EM
    
• β-2 adrenergic receptor
  • 6kr8 - hB2AR
    
  • 3pds - hB2AR/T4 lysozyme
    
  • 3p0g – hB2AR/T4 lysozyme + nanobody
    
  • 4lde, 4ldl, 4ldo - hB2AR/T4 lysozyme (mutant) + nanobody
    
  • 2r4s,2r4r - hB2AR + Fab5 complex
    
  • 2rh1 - hB2AR/T4 lysozyme (mutant)
    
  • 3d4s, 5d6l - hB2AR/T4 lysozyme (mutant) + cholesterol
    
  • 4gbr - hB2AR/T4 lysozyme (mutant) + carazolol
    
  • 6mxt - hB2AR/T4 lysozyme (mutant) + antibody + salmeterol
    
  • 5x7d - hB2AR/T4 lysozyme (mutant) + carazolol + inhibitor
    
  • 6oba - hB2AR/T4 lysozyme (mutant) + modulator
    
  • 6ps0, 6prz, 6ps2, 6ps3, 6ps4, 6ps5, 6ps6 - hB2AR + cholesterol + carazolol derivative
    
  • 6ps1 - hB2AR + cholesterol + timolol
    
  • 5d5a, 5d5b - hB2AR (mutant) + cholesterol + carazolol
    
  • 5jqh - hB2AR/T4 lysozyme (mutant) + carazolol + nanobody
    
  • 3ny8, 3ny9, 3nya – hB2AR/T4 lysozyme + agonist
    
  • 7xka – hB2AR/endolysin + nanobody + epinephrine
    
  • 7xk9 – hB2AR/endolysin + nanobody + isoproterenol
    
  • 8zbe – hB2AR /endolysin+ guanine nucleotide-binding protein + scFv + octreotide– Cryo EM
    
  • 8jjl – hB2AR/cytochrome b562 + agonist – Cryo EM
    
  • 8jj8 – hB2AR/cytochrome b562 + partial agonist – Cryo EM
    
  • 8jjo – hB2AR/cytochrome b562 + antagonist – Cryo EM
    
  • 8uhb – hB2AR/cytochrome b562/TRACE amine-associated receptor + guanine nucleotide-binding proteins + nanobody – Cryo EM
    
  • 6n48 - hB2AR/endolysin + nanobody + modulator
    
  • 3sn6 - hB2AR + nanobody bound by guanine nucleotide-binding protein G
    
  • 8w1v - hB2AR + nanobody + bitopic ligand
    
  • 7bz2, 7dhi, 7dhr – hB2AR + guanine nucleotide-binding protein + nanobody + modulator – Cryo EM
    
  • 8gdz, 8ge1, 8ge2, 8ge3, 8ge4, 8ge5, 8ge6, 8ge7, 8ge8, 8ge9, 8gea, 8geb, 8gec, 8ged, 8gee, 8gef, 8geg, 8geh, 8gei, 8gej – hB2AR + guanine nucleotide-binding protein – Cryo EM
    
  • 8gfv, 8gfw, 8gfx, 8gfy, 8gfz, 8gg0, 8gg1, 8gg2, 8gg3, 8gg4, 8gg5, 8gg6, 8gg7, 8gg8, 8gg9, 8gga, 8ggb, 8ggc, 8gge, 8ggf, 8ggi, 8ggj, 8ggk, 8ggl, 8ggm, 8ggn, 8ggo, 8ggr, 8ggs, 8ggt, 8ggu, 8ggw, 8ggv, 8ggx, 8ggy, 8ggz, 8gh0, 8gh1, 8unl, 8unm, 8unn, 8ggp, 8ggq, 8uno, 8unp, 8unq, 8unr, 8uns, 8unt, 8unu, 8unv, 8unw, 8unx, 8uny, 8unz, 8uo0, 8uo1, 8uo2, 8uo3, 8uo4 – hB2AR + guanine nucleotide-binding protein + GTP – Cryo EM
    
  • 8zcj – hB2AR + guanine nucleotide-binding protein + scFv + cyclic peptide – Cryo EM
    
  • 3kj6, 2r4r, 2r4s – hB2AR + FAB heavy+light chains
    
  • 9chu, 9chv, 9chx - hB2AR/calcineurin + phosphatase + FKBP1A + carazolol – Cryo EM
    
  • 4qkx – B2AR + R9 protein - llama
    
• β-3 adrenergic receptor
  • 9ijd – hB3AR + guanine nucleotide-binding protein + scFv + VHH + carazolol - Cryo EM
    
  • 9ije – hB3AR + guanine nucleotide-binding protein + scFv + VHH + adrenaline + epinephrine - Cryo EM
    
  • 7dh5, 7xjh, 7xji – B3AR + guanine nucleotide-binding protein + nanobody + drug – dog - Cryo EM
    

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Michal Harel