Aldose Reductase

spinqualitylabelsall models Human aldose reductase complex with cofactor NADP (PDB code 1ads) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. Disease The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. Structural highlights AldR structure is of a β/α-barrel. The active site is located in the barrel core. Active site interactions. Water molecules are shown as red spheres. Active site tunnel. 3D Structures of aldose reductase Aldose reductase 3D structures

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