Alpha-tubulin N-acetyltransferase

spinqualitylabelsall models Humanα-tubulin N-acetyltransferase catalytic domain complex with CoA (PDB code 3vwe) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Alpha-tubulin N-acetyltransferase (TAT) catalyzes the conversion of acetyl-CoA and tubulin-L-lysine to CoA and tubulin-N-acetyl-L-lysine. TAT acetylates Lys40 in tubulin and is required for normal sperm flagellar function. This posttranslational modification of tubulin is conserved in long-lived microtubules. TAT can acetylate itself and this acts as a regulatory mechanism for its action on tubulin. CoA binding site of α-tubulin N-acetyltransferase (PDB code 3vwe). Water molecules are shown as red spheres. 3D Structures of alpha-tubulin N-acetyltransferase Alpha-tubulin N-acetyltransferase 3D structures

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