Aminotransferase

spinqualitylabelsall models E. coli Histidinol-phosphate aminotransferase complex with PLP (PDB code 1gew) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Aminotransferase or transaminase catalyze the reversible exchange of amino group of an amino acid with a keto group of an alpha-keto acid. Aminotransferases use pyridoxal phosphate (PLP) as cofactor. Histidinol-phosphate aminotransferase (HPA) catalyzes the interconversion of L-histidinol phosphate and 2-oxoglutarate to L-glutarate and 3-(imidazole-4-yl)-2-oxopropyl phosphate. HPA is part of the metabolism of histidine, phenylalanine and tyrosine. Gamma-aminobutyrate aminotransferase (GABA) catalyzes the intercorversion of 4-aminobutanoate and 2-oxoglutarate to succinate semialdehyde and L-glutamate. Aspartate aminotransferase (AAT) catalyzes the intercorversion of aspartate and α-ketoglutarate to oxaloacetate and glutamate. For details on AAT see Aspartate Aminotransferase. Phosphoserine aminotransferase (PSAT) catalyzes the intercorversion of phosphoserine and oxoglutarate to phosphonooxypyruvate and glutamate. For details on PSAT see Phosphoserine aminotransferase. Alanine glyoxylate aminotransferase (AGA) catalyzes the intercorversion of alanine and glyoxate to methyloxopropanoate and glycine. D-amino acid aminotransferase (AAT) catalyzes the intercorversion of D-alanine and oxoglutarate to pyruvate and D-glutamate. Aromatic amino acid aminotransferase (AROAT) catalyzes the intercorversion of aromatic amino acid and oxoglutarate to aromatic oxo acid and glutamate. Lysine aminotransferase (LYSAT) catalyzes the intercorversion of lysine and oxoglutarate to aminoadipate semialdeyde and glutamate. ArnB aminotransferase is a PLP-dependent aminotransferase in the pathway of biosynthesis of arabinose-4N lipid A. PseC aminotransferase is an aminotransferase in the pathway of biosynthesis of pseudaminic acid. WbpE aminotransferase is a PLP-dependent aminotransferase in the pathway of biosynthesis of Pseudomonas aerugingsa central carbohydrate. See also Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis. Relevance Elevated levels of alanine aminotransferase and aspartate aminotransferase are indicators of liver damage. Structural highlights The active site of histidinol-phosphate aminotransferase contains PLP. 3D structures of aminotransferase Aminotransferase 3D structures

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