Ankyrin repeat domain-containing protein

spinqualitylabelsall models Human ARDCP 25 (cyan and green) complex with kinesin peptide (pink and yellow), sulfate and glycerol (PDB code 5ybv). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ankyrin repeat domain-containing protein (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain. Disease Mutations in ARDCP 3 manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities. Structural highlights The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues KARR interact in an acidic pocket and residues QMELLYA interact in a hydrophobic pocket. Whole kinesin peptide binding site. 3D structures of ankyrin repeat domain-containing protein Ankyrin repeat domain-containing protein 3D structures

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