Annexin

spinqualitylabelsall models Rat annexin V complex with Ca+2 (green) and sulfate (PDB code 1n42) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. Annexins divide into species and are numbered from I to XII. Annexin I is involved in a variety of pathways. Annexin II is involved in angiogenesis, tutor progression and metastasis. See also Ezetimibe. Annexin V is the most abundant scaffolding protein. Annexin VI is involved in endocytosis and regulates entry of ligands to prelysosomal compartment. Annexin VIII is calcium-dependent phospholipid-binding involved in blood coagulation. Annexin E1 (AnE1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella. Annexin A-V has a major role in coagulation. Relevance Annexin I is involved in anti-inflammatory responses and apoptotic mechanisms. Structural highlights Annexins consist of 2 domains - the C-terminal core and the N-terminal head. The core domain consists of 4 annexin repeats containing 5 helices. The core domain concave side contains the Ca+2 binding sites. 3D structures of annexin Annexin 3D structures

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