Function
Phosphoglucose isomerase (PGI) or glucose-6-phosphate isomerase catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate[1]. The encoded protein is also referred to as autocrine motility factor (AMF) based on an additional function as a tumor-secreted cytokine and angiogenic factor (see Growth factors). PGI is part of the glycolysis cycle. For more details see Phosphoglucoisomerase.
Disease
Increased expression of PGI enhances colorectal cancer metastasis[2].
Structural highlights
Rabbit PGI active site containing the substrate D-fructose 6-phosphate shows the substrate interacting mainly with residues of one subunit[3]. Water molecules are shown as red spheres.
3D Structures of phosphoglucose isomerase
Phosphoglucose isomerase 3D structures
- ↑ Bahaji A, Sanchez-Lopez AM, De Diego N, Munoz FJ, Baroja-Fernandez E, Li J, Ricarte-Bermejo A, Baslam M, Aranjuelo I, Almagro G, Humplik JF, Novak O, Spichal L, Dolezal K, Pozueta-Romero J. Plastidic phosphoglucose isomerase is an important determinant of starch accumulation in mesophyll cells, growth, photosynthetic capacity, and biosynthesis of plastidic cytokinins in Arabidopsis. PLoS One. 2015 Mar 26;10(3):e0119641. doi: 10.1371/journal.pone.0119641., eCollection 2015. PMID:25811607 doi:https://dx.doi.org/10.1371/journal.pone.0119641
- ↑ Tsutsumi S, Fukasawa T, Yamauchi H, Kato T, Kigure W, Morita H, Asao T, Kuwano H. Phosphoglucose isomerase enhances colorectal cancer metastasis. Int J Oncol. 2009 Nov;35(5):1117-21. PMID:19787266
- ↑ Lee JH, Chang KZ, Patel V, Jeffery CJ. Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate. Biochemistry. 2001 Jul 3;40(26):7799-805. PMID:11425306
