Beta secretase 3D structures

3D Structures of Beta secretase

Updated on 03-November-2022

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• BACE-1
  • 2zhs, 2zht, 2zhu, 2zhv, 1sgz - hBACE-1 catalytic domain – human
    
  • 1w50, 3tpj, 3tpl, 3zkg - hBACE-1 catalytic domain (mutant)
    
  • 3k5d, 3k5f, 3k5g, 3ixj, 3kmx, 3kmy, 3kn0, 3ivh, 3ivi, 2vkm, 2hiz, 2hm1, 2g94, 1xs7, 4fm7, 4fm8, 4gid, 4i0h, 5dqc, 5qco, 5qcp, 5qcq, 5qcr, 5qcs, 5qct, 5qcu, 5qcv, 5qcw, 5qcx, 5qcy, 5qcz, 5dq1, 5dq2, 5dq3, 5dq4, 5dq5, 5dq6, 5dq7, 5dq8, 5dq9, 5dqa, 5dqb, 5dqc, 5dqd, 6ej2, 6ej3, 7d2v, 7d2x, 7d36, 7d5a, 7dcz, 7f1d, 7myi, 7myr, 7myu, 7n66 – hBACE-1 catalytic domain+inhibitor
    
  • 3lhg, 3ind, 3in3, 3in4, 3ine, 3inf, 3inh, 3ooz, 3s7l, 3s7m, 4dju, 4djv, 4djw, 4djx, 4djy – hBACE-1 catalytic domain+ aminohydantoin inhibitor
    
  • 3fkt – hBACE-1 catalytic domain (mutant) + aminohydantoin inhibitor
    
  • 3k5c, 3l58, 3l59, 3l5b, 3l5c, 3l5d, 3l5e, 3l5f, 3duy, 3dv1, 3dv5, 2f3e, 2f3f, 1ym2, 1ym4, 3skf, 3skg, 4h1e, 4h3j, 4ha5, 4gmi, 4k8s, 4k9h, 6nv7, 6nv9, 6nw3 – hBACE-1 catalytic domain+ macrocyclic inhibitor
    
  • 3ckp, 3ckr, 2qzk, 2ph8, 2va5, 2va6, 2va7, 2ph6, 4ke0, 4ke1, 6uj1 – hBACE-1 catalytic domain (mutant) + macrocyclic inhibitor
    
  • 3ohh, 3ohf, 3n4l, 3nsh, 2iqg, 3pi5, 3qbh, 4dpf, 4dpi, 4dus, 4fs4, 4ewo, 4exg, 3veu, 3vf3, 3vg1, 4d83, 4d85, 4d88], 4d89, 4d8c, 3qi1, 4lxa, 4lxk, 4lxm – hBACE-1 catalytic domain+ hydroxyethylamine inhibitor
    
  • 3i25 – hBACE-1 catalytic domain+ hydroxyethylene inhibitor
    
  • 3udh, 2qmg, 2qmd, 2qmf, 3ufl, 3udj, 3udk, 3udm, 3udn, 3udp, 3udq, 3udr, 3udy, 3r2f, 3uqr, 6bfd, 6bfe, 6bfx – hBACE-1 catalytic domain+ pyrrolydine inhibitor
    
  • 2wez, 2wf0, 6bfd, 6bfe, 6bfx, 3hw1, 3uqp, 4dv9, 4dvf – hBACE-1 catalytic domain (mutant) + pyrrolydine inhibitor
    
  • 4lc7, 4rcd, 4rce, 4rcf, 4wtu, 5enm, 5enk, 5uyu, 6dhc – hBACE-1 catalytic domain+ oxazoline inhibitor
    
  • 4xkx, 5i3w, 5ezz, 5ezx, 5clm, 4fri, 4frj, 4frk – hBACE-1 catalytic domain (mutant) + oxazoline inhibitor
    
  • 5ygx, 5yxy – hBACE-1 catalytic domain + oxazine inhibitor
    
  • 6fgy – hBACE-1 catalytic domain (mutant) + oxazine inhibitor
    
  • 5v0n, 3lnk, 3lpi, 3lpj, 3lpk, 3cib, 3cic, 3cid, 3u6a, 6od6 – hBACE-1 catalytic domain + piperazine inhibitor
    
  • 2zjk, 2zjj - hBACE-1 catalytic domain (mutant) + piperazine inhibitor
    
  • 2zjh, 2zji, 2zjl, 2zjm, 2jzn, 2ohn, 4fco - hBACE-1 catalytic domain (mutant) + piperidine inhibitor
    
  • 6bfw – hBACE-1 catalytic domain + morpholine inhibitor
    
  • 2of0 – hBACE-1 catalytic domain (mutant) + morpholine inhibitor
    
  • 6c2i, 4i0j, 6jse, 6jsf, 6jsn, 6jt3, 6jt4, 6pz4 – hBACE-1 catalytic domain + pyrazine inhibitor
    
  • 5qd0 – hBACE-1 catalytic domain + pyrazole inhibitor
    
  • 3kyr, 3dm6 – hBACE-1 catalytic domain + statine inhibitor
    
  • 2qk5, 2qp8, 2p8h, 2p4j, 2p83, 2fdp, 3ixk, 3tpr – hBACE-1 catalytic domain + phthalamide inhibitor
    
  • 2qzl, 2is0, 2b8l, 3tpp – hBACE-1 catalytic domain (mutant) + phthalamide inhibitor
    
  • 3wb4, 3wb5, 5he7, 5he5, 5he4, 5hdz, 5hdx, 5hdv, 5hdu, 5hd0, 4frs, 3vv6, 3vv7, 3vv8, 4h3f, 4h3g, 4h3i, 4l7g, 4l7h, 4l7j - hBACE-1 catalytic domain + pyrimidine inhibitor
    
  • 3zki, 3hvg, 3exo - hBACE-1 catalytic domain (mutant) + pyrimidine inhibitor
    
  • 3igb, 4acu, 4b1c, 4b1d, 4b1e, 4b70, 4b72, 4b77, 4n00, 3msj, 3msk, 3msl, 3s2o, 4joo, 4jp9, 4jpc, 4jpe – hBACE-1 catalytic domain+ imidazole inhibitor
    
  • 4acx – hBACE-1 catalytic domain (mutant) + imidazole inhibitor
    
  • 2zdz, 2ze1, 2qu2, 2qu3, 4fse, 4fsl, 4b0q – hBACE-1 catalytic domain+ acyl guanidine inhibitor
    
  • 4ivs, 4ivt – hBACE-1 catalytic domain (mutant) + acyl guanidine inhibitor
    
  • 2q11, 2q15, 4i0e, 4i0f, 4i0g, 4i10, 4i11, 4i12, 4i1c, 5mxd, 2wjo – hBACE-1 catalytic domain+ quinazoline inhibitor
    
  • 2vnm, 2vnn, 2vie, 2vij, 2viy, 2viz, 2vj6, 2vj7, 2vj9, 4dh6, 4di2 – hBACE-1 catalytic domain (mutant) + hydroxyethylamine inhibitor
    
  • 4b78, 3l38, 3l3a, 6eqm, 6dmi, 6e3z, 6jsg, 6uvp, 7b1e, 7b1p, 7b1q, 7d2v, 7d2x, 7d5a, 7dcz – hBACE-1 catalytic domain + pyridine inhibitor
    
  • 2ohq, 2ohr, 2ohs, 2oht, 2ohu, 2ohp, 4j0p, 2ntr, 2ohm, 4azy, 4b00, 4b05, 3zmg, 4j0t, 4j0v, 4j0y, 4j0z, 4j1i, 4j1k, 3zov, 4bfd – hBACE-1 catalytic domain (mutant) + pyridine inhibitor
    
  • 2b8v, 2irz, 2xfi, 2xfj, 2xfk, 1w51 – hBACE-1 catalytic domain (mutant) + benzamide inhibitor
    
  • 4pzw, 4pzx, 4r5n, 4rrn, 4rro, 4rrs, 4wy1, 4wy6 – hBACE-1 catalytic domain + pyranochromene inhibitor
    
  • 4r8y, 4r91, 4r92, 4r93, 4r95, 3h0b – hBACE-1 catalytic domain + iminoheterocycle inhibitor
    
  • 4x2l, 4x7i, 5kqf, 5hu1, 4zsr, 4zsq, 4zsp, 4zsm, 4zpg, 4zpf, 4zpe, 4ybi, 4xxs, 6uvv, 6uvy, 6uwp, 6uwv – hBACE-1 catalytic domain + thiazine inhibitor
    
  • 5tol, 5kr8, 4bek – hBACE-1 catalytic domain (mutant) + thiazine inhibitor
    
  • 5t1w, 5t1u – hBACE-1 catalytic domain + aminomethyl inhibitor
    
  • 3bra, 3buf, 3bug, 3buh - hBACE-1 catalytic domain (mutant) + aminomethyl inhibitor
    
  • 5hu0, 5htz – hBACE-1 catalytic domain + thiadiazinane inhibitor
    
  • 2wf1, 2wf2, 2wf3, 2wf4 - hBACE-1 catalytic domain (mutant) + thiazepine inhibitor
    
  • 4trz, 4try, 4trw – hBACE-1 catalytic domain + peptide mimetic inhibitor
    
  • 5ie1, 4hzt, 4i0z – hBACE-1 catalytic domain + quinoline inhibitor
    
  • 3rsv, 3rsx, 3rth, 3rtm, 3rtn, 3ru1, 3rvi, 5i3y, 5i3x, 5i3v, 5f01, 5f00, 2ohk, 2ohl – hBACE-1 catalytic domain (mutant) + aminoquinoline inhibitor
    
  • 4i0d, 4i0i – hBACE-1 catalytic domain + thiophene inhibitor
    
  • 4acx – hBACE-1 catalytic domain (mutant) + aminoimidazole inhibitor
    
  • 2zhr, 1xn2, 1xn3, 1m4h, 1fkn, 5mcq - hBACE-1 catalytic domain + peptide inhibitor
    
  • 5mbw, 5mco, 6uj0 - hBACE-1 catalytic domain (mutant) + peptide inhibitor
    
  • 6wny – hBACE-1 catalytic domain + fluoro-olefin inhibitor
    
  • 2oah, 1tqf, 3uqp, 3uqr, 3uqu, 3uqw, 3uqx, 4fgx - hBACE-1 catalytic domain (mutant)+inhibitor
    
  • 3r1g - hBACE-1 catalytic domain + FAB
    
• BACE-2
  • 3zkg - hBACE-2 extracellular domain (mutant)
    
  • 2ewy - hBACE-2 residues 16-398 + inhibitor
    
  • 3zlq - hBACE-2 extracellular domain (mutant) + inhibitor
    
  • 3zl7 - hBACE-2 extracellular domain + fynomer
    
  • 3zkm, 3zkn - hBACE-2 extracellular domain + FAB
    
  • 3zkq, 3zks, 3zkx, 4bel, 4bfb - hBACE-2 extracellular domain + xaperon
    
  • 6jsz, 7d5b, 7d5u, 7f1g, 7n4n - hBACE-2 extracellular domain + xaperon + pyrazine inhibitor
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel