CD1

spinqualitylabelsall models Structure of mouse CD1 extracellular domain (magenta) containingβ-microglobulin (green) complex with glycolipid (PDB entry 3ilp) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D CD1 (or Cluster of Differentiation 1 or T-cell surface glycoprotein CD1 or antigen-presenting glycoprotein CD1) is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules. Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid (PDB entry 3ilp).

3D Structures of CD1

Updated on 15-November-2022

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• CD1 or T-cell surface glycoprotein CD1
  • 3ilp – mCD1 extracellular domain + β-microglobulin - mouse
    
  • 3gmq – mCD1d extracellular domain + β-microglobulin
    
• CD1 complex with glycolipid
  • 1onq, 1xz0, 4x6e, 4x6f, 5j1a, 6nux, 7koz, 7kp0, 7kp1, 7koz, 7sh4 – hCD1a + β-microglobulin + lipid - human
    
  • 1gzp, 1gzq, 1uqs, 2h26, 3t8x, 5l2j, 5wke, 5wkg, 5wl1, 6d64 – hCD1b + β-microglobulin + lipid
    
  • 3l9r – bCD1b3 + β-microglobulin + lipid - bovine
    
  • 3ov6, 4ono, 5c9j, 6c15 – hCD1c + β-microglobulin + lipid
    
  • 3u0p, 4mq7 – hCD1d + β-microglobulin + lipid
    
  • 1zt4, 4f7c, 4f7e – bCD1d + β-microglobulin + lipid
    
  • 6v7y, 6v7z – hCD1d1 + β-microglobulin + nanobody
    
  • 3s6c – hCD1e + β-microglobulin + lipid
    
  • 1zhn, 2akr, 2fik, 2gaz, 2q7y, 3au1, 3go8, 3g0m, 3gml, 3gmm, 3gmn, 3gmo, 3gmp, 3gmr, 3ilp, 3ilq, 3t1f, 3ma7, 4mx7, 5efi,[ 5fkp, 5tw2, 5tw5, 6c5m 6c69, 6c6a, 6c6c, 6c6e, 6c6f, 6c6h, 6c6j, 6cyw, 6ojp – mCD1d1 extracellular domain + β-microglobulin + lipid
    
  • 4mng – mCD1d1 (mutant) + β-microglobulin + lipid
    
  • 6bmh, 6bmk – mCD1d2 extracellular domain + β-microglobulin + lipid
    
  • 1z5l – mCD1 extracellular domain + β-microglobulin + ganglioside
    
  • 3ubx, 6oor – mCD1d1 extracellular domain + β-microglobulin + antibody
    
• CD1 complex with glycolipid and T-cell receptor (TCR) protein
  • 7rym, 7ryn – hCD1a + β-microglobulin + TCR
    
  • 4x6c, 4x6d, 7ryo – hCD1a + β-microglobulin + lipid + TCR
    
  • 4wo4, 5l2k, 5wki, 6cug – hCD1b + β-microglobulin + lipid + TCR
    
  • 6c09 – hCD1c + β-microglobulin + lipid + TCR
    
  • 2po6, 3huj, 3tzv, 3vwj, 4en3, 4lhu, 4ww2, 4wwk – hCD1d + β-microglobulin + lipid + TCR
    
  • 6v80 – hCD1d1 + β-microglobulin + nanobody + TCRBR />
  • 3he6, 3he7, 3o8x, 3o9w, 3arb, 3ard, 3are, 3arf, 3arg, 3qux, 3quy, 3quz, 3rug, 3rzc, 3scm, 3sda, 3sdc, 3sdd, 3ta3, 3tn0, 3to4, 3tvm, 3qi9, 3rtq, 4apq, 4ei5, 4elm, 4irj, 4irs, 4y16, 4zak, 5vcj, 6bnk, 6bnl, 6cw6, 6cw9, 6cwb, 6cwe, 6cx5, 6cx7, 6cx9, 6cxa, 6cxe, 6cxf, 6miv, 6miy, 6mj4, 6mj6, 6mja, 6mji, 6mjj, 6mjq, 6mss, 6omg, 7m72 – mCD1d1 extracellular domain + β-microglobulin + lipid + TCR NKT
    
  • 1z5l – mCD1 extracellular domain + β-microglobulin + ganglioside
    

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Michal Harel, Alexander Berchansky