CD3

spinqualitylabelsall models Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry 1sy6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD3 (or Cluster of Differentiation 3) is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). Human CD3 extracellular domain with antibody light chain and heavy chain (PDB entry 1sy6). Relevance Drugs which bind to CD3 are tested as immunorepressants. 3D structures of CD3 CD3 3D structures

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Michal Harel, Alexander Berchansky