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Function
CD44 is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.[1]
Relevance
CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.
- ↑ Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:https://dx.doi.org/10.1107/S2053230X14015532
- ↑ Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201
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3D structures of CD44
Updated on 20-January-2025
2jcq, 4pz4 – hCD44 hyaluronan-binding domain 18-171 – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide
2jcp - mCD44 hyaluronan-binding domain 23-172 – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, , 4np3, 5bzc, 5bzk, 5sbk, 5sbl, 5sbm, 5sbn, 5sbo, 5sbp, 5sbq, 5sbr, 5sbs, 5sbt, 5sbu, 5sbv, 5sbw, 5sbx, 5sby, 5sbz, 5sc0, 5sc1, 5sc2, 5sc3, 5sc4, 5sc5, 5sc6, 5sc7 - mCD44 hyaluronan-binding domain + inhibitor
5bze, 5bzf, 5bzg, 5bzh, 5bzi, 5bzj, 5bzl, 5bzm, 5bzn, 5bzo, 5bzp, 5bzq, 5bzr, 5bzs, 5bzt - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide
References
