CREB-binding protein

spinqualitylabelsall models Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions 3p1c Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CREB-binding protein or CREBBP (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. Disease Mutations in CBP cause Rubinstein-Taybi syndrome. Structural highlights CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73. Acetyllysine binding site with chain A. Water molecules are shown as red spheres. Acetyllysine binding site with chain B (3p1c). 3D Structures of CREB-binding protein CREB-binding protein 3D structures

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