CXC chemokine receptor

spinqualitylabelsall models Human CXCR4/lysozyme chimera complex with antagonist citrulline (PDB code 3oe0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D CXC chemokine receptors bind to cytokines of the CXC chemokine family. CXCR4 is specific for Stromal Derived Factor 1 (SDF-1α, known also as CXCL12). CXCR1 recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif. CXCR2 is a critical mediator of neutrophil-mediated host defense in Pseudomonas pneumonia. CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a dimer . CXCR7 is involved in aortic and pulmonary stenosis Ligand binding cavity with antagonist citrulline (PDB code 3oe0). Ligand binding cavity with antagonist citrulline, receptor is in spacefill representation. Ligand binding cavity with antagonist citrulline, receptor surface is shown.

3D Structures of CXC chemokine receptor

Updated on 09-June-2024

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• CXC chemokine receptor type 1
  • Stromal Derived Factor 1 – hCXCR1 residues 29-324
    
• CXC chemokine receptor type 2
  • 3oe0– hCXCR2/GLGA glycogen synthase
    
• CXC chemokine receptor type 4
  • 3odu – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161+antagonist – human
    
  • 3oe0, 3oe6, 3oe8, 3oe9, 4rws – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161/hCXCR4 residues 231-319+antagonist
    
  • 2k03, 2k04, 2k05 - hCXCR4 N-terminal (mutant)+ hSDF-1 (mutant) - NMR
    
  • 2n55– hCXCR4 N-terminal + stromal cell-derived factor 1
    
• CXCR chemokine receptor type 7
  • 6qzh– hCXCR7/sialidase + benzamide derivative
    

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