Calcium/Calmodulin-dependent protein kinase

spinqualitylabelsall models Human CamKII subunitα kinase domain complex with indirubin (PDB code 2vz6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. CaMKI is a specialized CaM kinase. CaMKII is multifunctional kinase. CaMKIII phosphorylates eukaryotic elongation factor 2. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. For details see Calcium-dependent protein kinase. Structural highlights CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of Thr 286 and Thr 305 (T305 is not in the pdb file). 3D Structures of Calcium/calmodulin dependent protein kinase Calcium/calmodulin dependent protein kinase 3D structures

References

See Calcium-dependent protein kinase

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