Catechol O-methyltransferase

spinqualitylabelsall models Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry 3a7e) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Catechol O-methyltransferase (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. For more details see Student Projects for UMass Chemistry 423 Spring 2012-6. Relevance The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment. Structural highlights Active site of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry 3a7e). Water molecule is shown as red sphere. 3D Structures of catechol O-methyltransferase Catechol O-methyltransferase 3D structures

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