Ceruloplasmin

spinqualitylabelsall models Glycosylated human ceruloplasmin complex with Cu+2 ions (orange) and O atoms (red) (PDB entry 1kcw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ceruloplasmin (CP) is a ferroxidase which is the major copper-carrying protein in the blood. It functions in iron metabolism. Relevance CP testing is used in diagnosis of the rare inherited disorder - Wilson disease. Disease CP mutation causes the autosomal recessive disorder - Aceruloplasminemia which results in accumulation of iron in the brain. Structural highlights Cu-O-Cu coordination site and Cu-O coordination site in human ceruloplasmin (PDB entry 1kcw).

3D structures of ceruloplasmin

Updated on 11-February-2019

1kcw, 2j5w, 4enz – hCP - human
4ejx – hCP + myeloperoxidase
5n0k, 5n4l – CP – rat

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Michal Harel, Alexander Berchansky