Cholesterol oxidase

spinqualitylabelsall models Cholesterol oxidase complex with steroid substrate (PDB entry 1coy) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cholesterol oxidase (COX) catalyzes the conversion of cholesterol and molecular oxygen to Colest-4-en-3-one and hydrogen peroxide. COX uses FAD as a cofactor. COX I binds FAD non-covalently whereas COX II binds FAD covalently. Relevance COX is used as a biosensor for the detection of cholesterol in blood serum and food. Structural highlights There are predominantly hydrophobic/non-polar residues in steroid substrate binding site (Hydrophobic, Polar) in COX. FAD binding site (PDB entry 1coy). Water molecules are shown as red spheres. Whole active site.

3D structure of cholesterol oxidase

Updated on 12-May-2019

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• Cholesterol oxidase
  • 1coy, 1i19 – BsCOX – Brevibacterium sterolicum
    
  • 1b4v, 1mxt, 1n1p, 1n4u, 1n4v, 1n4w, 2gew, 4u2l, 4u2s, 4u2t, 5kwf, 4xxg, 4xwr, 4rek – StCOX – Streptomyces
    
  • 1b8s, 1cbo, 1cc2, 1ijh, 3b6d, 3cnj, 3gyi, 3gyj – StCOX (mutant)
    
  • 3js8 – COX – Chromobacterium
    
• Cholesterol oxidase complex
  • 1coy, 3cox – BsCOX + steroid
    
  • 3b3r - StCOX (mutant) + glycerol

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