Chymotrypsin 3D structures

3D Structures of Chymotrypsin

Updated on 28-January-2025

The Chy precursor is the inactive chymotrypsinogen (Chygen) which gets cleaved 3 times by trypsin and chymotrypsin losing a 4 amino acid long peptide to become the active Chy. γ-Chy is a covalent acyl adduct of α-Chy. δ-Chy results when Chygen is cleaved only twice.

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• Native α-chymotrypsin
  • 1yph, 4cha, 5cha – bChy chain A - bovine
    
  • 6di8 – bChy chain A+B+C
    
  • 1kdq – rChy chain B (mutant) - rat
    
  • 2ea3 – Chy – Cellulomonas bogoriensis
    
• α-chymotrypsin + polypeptide inhibitors
  • 4h4f – hChyC +Elgin C - human
    
  • 1cbw, 1mtn, 7qiq - bChy+BPTI
    
  • 1t7c, 1t8l, 1t8m, 1t8n, 1t8o – bChyA+P1 BPTI variants
    
  • 1oxg – bChyA+autolysis peptide
    
  • 4q2k - bChyA+ cyclic peptide
    
  • 1p2m, 1p2n, 1p2o, 1p2q – bChyA+ 4 amino acids in S1 pocket
    
  • 1n8o – bChyA+ecotin
    
  • 1ca0 – bChy+APPI
    
  • 1gl1 – bChy + PMP-C
    
  • 1ab9, 8gch, 1gct, 2gct, 3gct, 2gch - bChyA + peptide
    
  • 1acb – bChy+Elgin C
    
  • 1cho, 1hja – bChyA+turkey ovomucoid third domain
    
  • 7jrx – bChy + kunitz-type inhibitor
    
• α-chymotrypsin + inhibitors
  • 3bg4 – bChyA chain A+guamerin
    
  • 2p8o - bChyA chain A+benzohydroxamic acid/vanadate
    
  • 2cha – bChyA+p-sulfinotoluene
    
  • 6cha – bChyA+phenylethane boronic acid
    
  • 1eq9 – Chy+PMSF – fire ant
    
• γ-Chymotrypsin + inhibitors
  • 1gg6 – γ-bChy+N-acetyl-phenylalanine trifluoromethyl ketone
    
  • 1ggd – γ-bChy+N-acetyl-phenylalanine trifluoromethyl aldehyde
    
  • 1afq - γ-bChy+synthetic inhibitor
    
  • 3gch, 4gch, 5gch - γ-bChyA+cinnamate
    
  • 6gch, 7gch - γ-bChyA+trifluoromethy ketone
    
  • 1gmc, 1gmd – γ-bChyA+ peptide
    
  • 2gmt - γ-bChy+N-acetyl-alanyl-phenylalanyl-chloroethyl ketone
    
  • 1gmh, 1gcd - γ-bChyA+organophosphoryl
    
  • 1gha, 1ghb - γ-bChyA+ N-acetyl-tryptophan
    
  • 1vgc, 2vgc, 3vgc, 4vgc – γ-bChy + boronic acid inhibitor
    
• Native Chymotrypsinogen
  • 2cga, 1chg, 1ex3, 7kty, 7ktz, 7ku0, 7ku1, 7ku2, 7ku3 – bChygenA
    
  • 2jet – rChygenB chain A,B
    
• Chymotrypsinogen + inhibitors
  • 1k2i - bChygenA+7-hydroxycoumarin
    
  • 2y6t – bChygenA + ecotin
    
  • 3t62 - bChygenA + Kunitz-type proteinase inhibitor SHPI-1
    
  • 1cgi, 1cgj - bChygenA + Kazal-type inhibitor
    
  • 3ru4 - bChygenA + trypsin + Bowman-Birk inhibitor
    
  • 1pyt – bChygenC + procarboxipeptidase + proproteinase
    
  • 7qir, 7qis, 7qit - bChygenA + BPTI
    
  • 1gl0, 1gli – ChygenA+PMP_D2v – locust
    

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Michal Harel