Colicin I receptor

spinqualitylabelsall models E. coli colicin I receptor (cyan) complexed with colicin Ia receptor-binding domain (green) and lauryl dimethylamine oxide (PDB entry 2hdi) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Colicin I receptor (Cir) is a TonB-dependent transporter of E. coli outer membrane transports Fe+3 bound to catecholates. Cir is used by colicin Ia to penetrate the cell. Upon binding to colicin Ia Cir changes its conformation enabling the colicin to insert into the inner membrane forming a voltage-dependent ion channel resulting in killing the bacteria. Structural highlights Cir contains an N-terminal plug domain inserted inside a 22-stranded transmembrane β barrel. The colicin Ia R domain interacts with Cir plug domain.

3D Structures of Colicin I receptor

Updated on 18-February-2019

colicin – EcCir – Escherichia coli
2hdi – EcCir + colicin Ia receptor-binding domain

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Michal Harel, Alexander Berchansky