Function
Crystallin is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. α-, β-, γ-, δ-crystallin are named according to the order they are eluted by gel filtration.
- Alpha crystallin has chaperone-like properties like the ability to prevent precipitation of denatured proteins[1]. See Alpha crystallin.
- Gamma crystallin is found mainly in the nuclear region of the lens[2].
- . δ-crystallin is found in avian and reptilian lenses and missing from fish, amphibia and mammals lenses[3].
Disease
Mutations in α-A-crystallin and α-B-crystallin can cause myopathy[4]. Several human cataracts have been linked to mutations in γ-D-crystallin[5].
3D Structures of Crystallin
Crystallin 3D structures
- ↑ Augusteyn RC. alpha-crystallin: a review of its structure and function. Clin Exp Optom. 2004 Nov;87(6):356-66. doi: 10.1111/j.1444-0938.2004.tb03095.x. PMID:15575808 doi:https://dx.doi.org/10.1111/j.1444-0938.2004.tb03095.x
- ↑ Vendra VP, Khan I, Chandani S, Muniyandi A, Balasubramanian D. Gamma crystallins of the human eye lens. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):333-43. PMID:26116913 doi:10.1016/j.bbagen.2015.06.007
- ↑ Piatigorsky J. Delta crystallins and their nucleic acids. Mol Cell Biochem. 1984;59(1-2):33-56. PMID:6369110 doi:10.1007/BF00231304
- ↑ Horwitz J. Alpha-crystallin. Exp Eye Res. 2003 Feb;76(2):145-53. doi: 10.1016/s0014-4835(02)00278-6. PMID:12565801 doi:https://dx.doi.org/10.1016/s0014-4835(02)00278-6
- ↑ Pande A, Pande J, Asherie N, Lomakin A, Ogun O, King J, Benedek GB. Crystal cataracts: human genetic cataract caused by protein crystallization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6116-20. PMID:11371638 doi:https://dx.doi.org/10.1073/pnas.101124798