CutA1 or periplasmic divalent cation tolerance protein is involved in copper tolerance in E. coli. In mammals it is implicated in the anchoring of acetylcholinesterase in the neural cell membrane. The thermostability of CutA1 from Pyrococcus horikoshii is extremely high.[1] See Divalent cation tolerant protein CUTA from Homo sapiens O60888.
Structural highlights
The copper ion is bound to Asp and Lys residues.
3D structures of CutA1
CutA1 3D structures
- ↑ Tanaka Y, Tsumoto K, Nakanishi T, Yasutake Y, Sakai N, Yao M, Tanaka I, Kumagai I. Structural implications for heavy metal-induced reversible assembly and aggregation of a protein: the case of Pyrococcus horikoshii CutA. FEBS Lett. 2004 Jan 2;556(1-3):167-74. PMID:14706845
