Cyclic GMP-AMP synthase

spinqualitylabelsall models Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code 4o67). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cyclic GMP-AMP synthase (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway. Disease Mice lacking CGAS are more vulnerable to lethal infection by DNA virus. Structural highlights The 2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS. 3D structures of cyclic GMP-AMP structures Cyclic GMP-AMP synthase 3D structures

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