Function
Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in pdb 4yc6 where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.
- CKS1 is essential for CDK5 functioning in neuronal differentiation.[1]
- CKS2 is implicated as an oncogene in various malignancies.[2]
Structural highlights
CKS exists as hexamer of homodimers and can bind six kinase molecules.
3D Structures of cyclin-dependent kinase regulatory subunit
Cyclin-dependent kinase regulatory subunit 3D structures
- ↑ Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379
- ↑ Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015
