Cystathionine beta-lyase

spinqualitylabelsall models E. coli cystathionineβ-lyase complex with PLP derivative and hepes (PDB code 4itg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cystathionine β-lyase (CBL) belongs to a family of PLP-dependent enzymes which cleave C β-S bonds in a variety of subtsrates. PLP is a pyridoxal phosphate. CBL catalyzes a reaction specific for methionine biosynthesis. CBL converts L-cystathionine to L-homocysteine, pyruvate and ammonia. Cystathionine γ-lyase (CGL) is PLP-dependent and breaks cystathionine to cysteine, ketobutyrate and ammonia. Disease CGL deficiency mediates neurodegeneration in Huntington's disease. Structural highlights The structure of the EcCBL shows 3 spatially different domains. The N-terminal domain (residues 1-60) contributes to the tetramer formation. The second domain (residues 61-256) binds to the PLP and the C-terminal domain (residues 257-395). Residue Lys210 binds to PLP and mediates the proton transfer between Cα and Sγ. PLP binding site. Water molecules are shown as red spheres.

3D structures of Cystathionine β-lyase

Updated on 20-February-2025

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• Cystathionine beta-lyase
  • 1ibj – CBL + PLP – Arabidopsis thaliana
    
  • 1cl1 – EcCBL + PLP derivative – Escherichia coli
    
  • 4itg – EcCBL (mutant) + PLP derivative
    
  • 1cl2 – EcCBL + aminoethoxy glycine
    
  • 2fq6, 2gqn – EcCBL + inhibitor
    
  • 4itx – EcCBL (mutant) + inhibitor
    
  • 6cja – LpCBL + PLP-Ala + Ser – Legionella pneumophila
    
  • 6cjb – LpCBL + PLP derivative
    
  • 6vju – LpCBL + PLP derivative + PLP
    
  • 6qp3 – CBL + PLP – Bacillus subtilis
    
  • 8duy – KpCBL – Klebsiella pneumoniae
    
  • 8u99 – KpCBL (mutant) + PLP + Ser
    
  • 8sa7, 8sa8 , 8saa, 8sac, 8sae – KaCBL (mutant) + PLP – Klebsiella aerogenes
    
  • 8sa9 – KaCBL (mutant) + PLP + oxamate
    
  • 8sad – KaCBL (mutant) + PLP + malonate
    
  • 8sab, 8u98 – KaCBL (mutant) + PLP + amino acid
    
  • 8juj – BcCBL + PLP – Bacillus cereus
    
  • 8jui – BcCBL + PLP derivative
    
• Cystathionine gamma-lyase
  • 1qgn – CGL + PLP – tobaco
    
  • 1n8p – CGL + PLP – yeast
    
  • 6ldo – LpCGL (mutant) + L-Ser – Lactobacillus plantarum
    
  • 6le4 – LpCGL (mutant) + cystathionine
    
  • 8biu, 8bix – TgCGL + PLP + cystathionine – Toxoplasma gondii
    
  • 8biv – TgCGL (mutant) + PLP
    
  • 8bis, 8biz – TgCGL + PLP + amino acid
    
  • 8biw – TgCGL (mutant) + PLP + amino acid
    
• Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase
  • 7md9 – SaBCGL (mutant) – Staphylococcus aureus
    
  • 7mcq – SaBCGL + inhibitor
    
  • 7md6, 7mda – SaBCGL (mutant) + inhibitor
    
  • 7mcl, 7mcn, 7mcp, 7md0 – SaBCGL + PLP
    
  • 7mcb, 7md1, 7md8 – SaBCGL (mutant) + PLP
    
  • 7mct, 7mcu, 7mcy – BCGL + inhibitor + PLP
    
  • 7mdb – BCGL (mutant) + inhibitor + PLP
    
  • 7d7o – BcBCBL + PLP
    

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Michal Harel, Alexander Berchansky