D-xylose isomerase

spinqualitylabelsall models Structure of D-xylose isomerase complex with D-xylose and Mn+2 ions (purple) (PDB code 1xld). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function D-xylose isomerase (DXI) catalyzes the conversion of D-xylose (DX) to D-xylitol. DXI is part of the fructose and mannose metabolism pathways. Sorbitol is a competitive inhibitor of DXI. DXI is a metal-ion activated tetramer. Relevance DXI is used commercially in the production of high fructose corn syrup. Structural highlights The biological assembly of D-xylose isomerase from Arthrobacter sp is homotetramer. DXI active site contains 2 Mn+2 ions and the ligand binding pocket is composed of aromatic and acidic residues (water molecules shown as red spheres). 3D structures of D-xylose isomerase D-xylose isomerase 3D structures

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