DNA methyltransferase

spinqualitylabelsall models Adenine DNMT complex with SAM and Cl- ion (PDB code 1nw5). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function DNA methyltransferase (DNMT) catalyzes the transfer of methyl group to DNA. Methylation is essential for gene expression. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT. Methylguanine DNMT repairs the DNA lesion O6-methylguanine to guanine. Methylcytosine DNMT methylates the 5 position of cytosine. Methyladenine DNMT methylates the 6 position of adenine. HhaI DNA methyltransferase (HDMT), a DNMT from Haemophilus haemolyticus recognizes the 5’-GCGC-3’ DNA sequence and methylates the first cytosine to convert it to 5-methylcytosine. The SAM serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. Relevance DNMT inhibitors are being tested in cancer therapy. Disease The human ICF disorder is caused by mutations in DNMT 3B. Structural highlights The active site of methyladenine DNMT contains the methyl donor SAM. 3D Structures of DNA methyltransferase DNA methyltransferase 3D structures

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Michal Harel, Alexander Berchansky