Dedicator of cytokinesis protein

spinqualitylabelsall models Human dedicator of cytokinesis protein 9 dimer DHR-2 domain (grey and aqua) complex with Cdc42 (green and olive) and GDP (PDB code 2wmn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dedicator of cytokinesis proteins (DOCK) are guanine-nucleotide exchange factors for Rho-family GTPase. DOCKs are required in cell motility and phagocytosis. DOCK1 is a regulator of cancer metastasis. DOCK2 is a regulator of various immune functions by activating Rac . DOCK3 is highly expressed in neutrons and is essential for cell growth and migration. DOCK5 has a role in regulating motile and invasive capacities of epithelial cells. DOCK7 is a regulator of DNA replication stress by promoting replication protein A stability in chromatin. DOCK8 is highly expressed in lymphocytes and regulates the actin cytoskeleton. DOCK10 is a regulator of dendritic spine morphogenesis via a Cdc42-mediated pathway. Disease Mutations in DOCK8 are found in patients diagnosed with an atypical form of hyper-IgE syndrome. Structural highlights Human dedicator of cytokinesis protein 9 DHR-2 domain (DOCK9) complex with Cdc42 and GDP (PDB code 2wmn). GDP interacts with Cdc42 (GTP-binding protein). Water molecules shown as red spheres. DOCK9 has extensive contacts with Cdc42. 3D structures of dedicator of cytokinesis protein Dedicator of cytokinesis protein 3D structures

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