Dehalogenase

spinqualitylabelsall models Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code 2edc). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dehalogenases catalyze the removal of halogen atom from substrates. • Haloalkane dehalogenase converts haloalkanes to alcohol • Halohydrin dehalogenase converts halohydrins to epoxide • L-2 haloacid dehalogenase converts L-2-haloacids to D-2-hydroxyacid • S-2 haloacid dehalogenase converts S-2-haloacids to R-2-hydroxyacid • 4-chlorobenzoyl CoA dehalogenase converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA • Fluoroacetate dehalogenase converts fluoroacetate to glycolate • Iodotyrosine dehalogenase converts iodotyrosine to tyrosine • cis- and trans-3-chloroacrylic acid dehalogenase converts 3-chloroacrylate to malonate semialdehyde • 5-chloromuconolactone dehalogenase converts 5-chloromuconolactone to E-dienelactone • Tetrachloroethene reductive dehalogenase catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor. Relevance Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products. Fluoroacetate dehalogenase is tested for the biodegredation of the poisonous fluroacetate which can kill livestock and is found in some plants in Australia, Africa and Central America. Halohydrin dehalogenase is used as a biocatalyst. Disease Iodotyrosine dehalogenase mutation is involved in congenital hypothyroidism. Structural highlights In the fluoroacetate dehalogenase complex with halide, the iodide is seen in the active site cavity between two tryptophans (in cyan). 3D structures of dehalogenase Dehalogenase 3D structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman