Deoxycytidine kinase

spinqualitylabelsall models Mouse deoxycytidine kinase complex with ADP and deoxycytidine (PDB entry 1p61) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Deoxycytidine kinase (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA (but not dT and dU) and nucleosides analogs which are used as antiviral and chemotherapeutic agents. Deoxyadenosine/deoxycytidine kinase (DACK) substrates ar cytidine, adenosine, arabinosylcytosine and arabinosyladenine . Relevance Deficiency of DCK causes resistance to antiviral and chemotherapeutic agents. Structural highlights The ability of DCK to phosphorylate multiple nucleosides arises from the different conformations which the active site glutamic acid can assume (active site glutamates are in yellow). 3D Structures of deoxycytidine kinase Deoxycytidine kinase 3D structures

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Michal Harel, Alexander Berchansky