Dethiobiotin synthetase (DTBS) or ATP-depenent dethiobiotin synthetase catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.[1]
Structural highlights
The active site contains the substrate (DAN), Mg+2 ion and ATP.[2]
3D dethiobiotin synthetase
Dethiobiotin synthetase 3D structures
- ↑ Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568
- ↑ Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910
