Dihydroorotase

spinqualitylabelsall models Dihydroorotate with ubunit A in deep sky blue and subunit B in green, complex with dihydroorotate, carbamoyl aspartate and Zn+2 ions (PDB ID 2z24) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dihydroorotase or amidohydrolase (DHO) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate in the pyrimidine biosynthesis pathway. Relevance The difference between bacterial and mammalian DHO makes it a promising drug target. Structural highlights The 3D structure of the complex of DHO with dihydroorotate and carbamoyl aspartate shows dihydroorotate bound to the protein subunit A active site these contacts includes electrostatic interactions. Water molecules are shown as red spheres. The substrate carbamoyl aspartate binds to the active site of subunit B. 3D structures of dihydroorotase Dihydroorotase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky