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DnaA or chromosomal replication initiator protein DnaA activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). [1]
Protein-DNA interface (1j1v).[2]
For more details see Molecular Playground/DNA replication initiator DnaA.
- ↑ Mott ML, Berger JM. DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol. 2007 May;5(5):343-54. PMID:17435790 doi:https://dx.doi.org/10.1038/nrmicro1640
- ↑ Fujikawa N, Kurumizaka H, Nureki O, Terada T, Shirouzu M, Katayama T, Yokoyama S. Structural basis of replication origin recognition by the DnaA protein. Nucleic Acids Res. 2003 Apr 15;31(8):2077-86. PMID:12682358
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3D structures of DnaA
Updated on 27-April-2025
1j1v – AaDnaA + ADP – Aquifex aeolicus
Molecular Playground/DNA replication initiator DnaA - AaDnaA + AMPPCP
3r8f - AaDnaA DNA binding domain + DNA
1j1v – EcDnaA DNA binding domain + DNA – Escherichia coli
2e0g - EcDnaA N terminal – NMR
2jmp - DnaA N terminal – Mycoplasma genitalium – NMR
2z4r, 2z4s - DnaA domain III – Thermotoga maritima
2wp0 - DnaA N terminal + HOBA – Helicobacter pylori
3pvp, 3pvv - DnaA DNA binding domain + DNA – Mycobacterium tuberculosis
4tps - BsDnaA domain I 1-82 + SirA – Bacillus subtilis
8bv3 - BsDnaA domain III 106-346
8btg - BsDnaA + DNA – Cryo EM
References
