Dual specificity phosphatase 3D structures

3D structures of dual specificity phosphatase

Updated on 30-April-2025

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• Dual specificity phosphatase
  • 6d66, 6d67 – hDUSP 1 (mutant)/MBP - human
    
  • 6apx – hDUSP 1 (mutant)/MBP + monobody
    
  • 6d65 – hDUSP 1 (mutant)/MBP + off7
    
  • 8tk4, 8tk5, 8tk6, 9dj9 – hDUSP 3
    
  • 3f81, 8tk2, 8tk3 – hDUSP 3 + inhibitor
    
  • 1j4x – hDUSP 3 (mutant) + peptide
    
  • 4y2e – hDUSP 7 catalytic domain (mutant)
    
  • 2hxp – hDUSP 9
    
  • 4jmj, 4mbb, 4nyh – hDUSP 11 (mutant) or RNA/RNP complex-1 interacting phosphatase
    
  • 4jnb, 4ki9 – hDUSP 12
    
  • 2gwo, 2pq5 – hDUSP 13
    
  • 5xjv – hDUSP 13A (mutant)
    
  • 2wgp – hDUSP 14
    
  • 1yz4 – hDUSP 15 catalytic domain (mutant)
    
  • 2vsw – hDUSP 16 rhodanese domain
    
  • 2esb – hDUSP 18
    
  • 3s4e – hDUSP 19
    
  • 4d3p, 4d3q, 4d3r – hDUSP 19 (mutant)
    
  • 1wrm, 6lvq – hDUSP 22
    
  • 6l1s, 6lmy, 6lot, 6lou, 7c8s – hDUSP 22 (mutant)
    
  • 4woh – hDUSP 22 (mutant) + nitrophenolphosphate
    
  • 4erc – hDUSP 23 + metavanadate
    
  • 2img – hDUSP 23 + malate
    
  • 2e0t, 4hrf – hDUSP 26
    
  • 4b04, 5gtj – hDUSP 26 (mutant)
    
  • 2y96 – hDUSP 27
    
  • 5y15, 5y16 – hDUSP 28 (mutant)
    
• hDUSP 5 see MAP kinase phosphatase MKP-3
  
• hDUSP 10 see MAP kinase phosphatase MKP-5
  
• hDUSP 14 see MAP kinase phosphatase MKP-6
  
• hDUSP 16 see MAP kinase phosphatase MKP-7
  
• Viral dual specificity phosphatase
  • 2q05, 2rf6, 3cm3 – DUSP – Vaccinia virus
    
  • 2p4d – DUSP – Variola virus
    
  • 7ncy – DUSP – Sulfolobales beppu filamentous virus
    
• Slingshot phosphatase (SSH)
  • 2nt2 – hSSH-2L catalytic domain - human
    
• Phosphatase of regenerating liver (PRL) or protein tyrosine phosphatase type IVA
  • 1rxd – hPRL-1
    
  • 1xm2 – hPRL-1 (mutant)
    
  • 5bx1 – hPRL-1 + inhibitor
    
  • 5k25, 5k23 – hPRL-2 + magnesium transporter
    
  • 5k22, 6wur – hPRL-2 (mutant) + magnesium transporter
    
  • 1r6h, 1v3a, 2mbc – hPRL-3 - NMR
    
  • 5tsr – hPRL-3 + magnesium transporter
    
  • 1zck, 1x24 – rPRL-1 - rat
    
  • 1zcl – rPRL-1 (mutant)
    
  • 3rz2 – rPRL-1 + peptide
    
  • 5mmz, 5lxq, 6wus – mPRL-1 + magnesium transporter - mouse
    
  • 5k24 – mPRL-2 + magnesium transporter
    
• Cdc14
  • 1ohc, 1ohd – hCdc14B2 core domain
    
  • 1ohe – hCdc14B2 core domain + peptide
    
  • 6g86 – hCdc14 + SIC1 peptide
    
  • 6g85, 6g84 – hCdc14 + CBK1 peptide
    
  • 5xw5 – hCdc14 + SWI6P peptide
    
  • 5xw4 – yCdc14 - yeast
    
  • 4zj7 – yCdc14 C-terminal + importin
    
• Cdc25
  • 8roz – hCdc25A catalytic domain + CDK2 + cyclin A2 – Cryo EM
    
  • 1qb0, 1cwr, 1cws, 1cwt, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq – hCdc25B catalytic domain
    
  • 2a2k, 2ifd, 2ifv – hCdc25B catalytic domain (mutant)
    
  • 4wh7 – hCdc25B catalytic domain (mutant) + ligand
    
  • 4wh9 – hCdc25B catalytic domain (mutant) + inhibitor
    
  • 3op3 – hCdc25C
    
  • 1t3k – Cdc25 – Arabidopsis thaliana - NMR
    
• Phosphoinositide phosphatase PTEN
  • 1d5r, 5bzz, 5bzx, 5bug – hPTEN (mutant)
    
• Phosphoinositide phosphatase Sac1
  • 3lwt – ySac1
    
  • 4tu3 – ySac1 + VPS74
    
• Phosphoinositide phosphatase Sac2
  • 4xuu – hSac2 residues 169-563
    
• Myotubularin-related protein (MTMR)
  • 1zvr – hMTMR2 PH-gram and phosphatase domains (mutant)
    
  • 1zsq - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate
    
  • 1m7r, 1lw3 - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate
    
  • 2yf0 – hMTMR6
    
• Myotubularin-related protein 15 (MTMR15) or Fanconi-associated nuclease 1
  • 4rid, 4ry3 – hMTMR15 residues 370-1009
    
  • 4rec, 4ri8, 4ri9, 4ria, 4rib, 4ric, 4reb, 4rea – hMTMR15 (mutant) + DNA
    
• MAPK phosphatase see MAP kinase phosphatase

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Michal Harel