Ectonucleoside triphosphate diphosphohydrolase

spinqualitylabelsall models Structure of NTDPase1 complex with GMPPNP, Na+ (purple), Cl- (large green), Mg+2 (small green) ions (PDB code 4brg). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Ectonucleoside triphosphate diphosphohydrolase (NTPDase) hydrolyzes nucleoside 5’-triphosphate to nucleoside 5’-phosphate and 2 phosphates. NTPDase can hydrolyze ATP and ADP. NTPDase has an important role in regulating neutrophil chemotaxis. NTPDase 1,2,3,8 are cell surface enzymes with catalytic sites facing extracellularly while other NTPDases act intracellularly. NTPDase require Ca+2 or Mg+2 for their activity. The NTPDases can be differentiated according to their substrate specificity, divalent cation usage and product formation. NTPDase 1 hydrolyzes ATP released by neutrophils. NTPDase 2 hydrolyzes extracellular ATP . NTPDase 3 hydrolyzes ATP in pancreatic beta-cells. NTPDase 4 hydrolyzes ATP in Golgi bodies.

3D structures of ectonucleoside triphosphate diphosphohydrolase

Updated on 06-May-2025

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• NTPDase1
  • 3zx3 – rNTPDase extracellular domain - rat
    
  • 3zx0, 3zx2 – rNTPDase extracellular domain + polyoxometallates
    
  • 5u7p – cNTPDase - clover
    
  • 5u7v – cNTPDase + AMP
    
  • 5u7w – cNTPDase + adenine
    
  • 5u7x – NTPDase - Vigna unguiculata
    
  • 3aap – LpNTPDase – Legionella pneumophila
    
  • 3aaq – LpNTPDase + inhibitor
    
  • 3aar – LpNTPDase + AMPPNP
    
  • 4jep – TgNTPDase – Toxoplasma gondii
    
  • 4a5b – TgNTPDase (mutant)
    
  • 4kh6 – TgNTPDase (mutant) + adenosine-imido-diphosphate
    
• NTPDase1 open form
  • 4br4, 4brm – LpNTPDase
    
  • 4br7, 4brc – LpNTPDase + adenosine-imido-diphosphate
    
• NTPDase1 closed form
  • 4br9, 4brp – LpNTPDase
    
  • 4bra – LpNTPDase + AMPPNP
    
  • 4brc – LpNTPDase + adenosine-imido-diphosphate
    
  • 4brd – LpNTPDase (mutant) + AMPPNP
    
  • 4bre – LpNTPDase + adenosine-5’-phosphovanadate
    
  • 4brh – LpNTPDase + thyamine-5’-phosphovanadate
    
  • 4brl – LpNTPDase + guanosine-5’-phosphovanadate
    
  • 4brf, 4brn – LpNTPDase + AMP
    
  • 4brg – LpNTPDase + GMPPNP
    
  • 4bri – LpNTPDase + UMPPNP
    
  • 4brk – LpNTPDase (mutant) + UMPPNP
    
  • 4brq – LpNTPDase + AMP + phosphate
    
• NTPDase1 part-open form
  • 4bro – LpNTPDase
    
  • 4bvp, 4bvo – LpNTPDase + polyoxometallates
    
• NTPDase2
  • 3cj1 – rNTPDase extracellular domain
    
  • 3cj7 – rNTPDase extracellular domain + AMP
    
  • 3cj9 – rNTPDase extracellular domain + AMP + phosphate
    
  • 3cja, 4br5 – rNTPDase extracellular domain + AMPPNP
    
  • 4bqz – rNTPDase extracellular domain + GMPPNP
    
  • 4br2 – rNTPDase extracellular domain + UMPPNP
    
  • 4br0 – rNTPDase extracellular domain + adenosine-imido-diphosphate
    
  • 4cd1 – rNTPDase extracellular domain + inhibitor
    
  • 4cd3 – rNTPDase extracellular domain (mutant) + inhibitor
    
• NTPDase3
  • 4a57 – TgNTPDase
    
  • 4a59 – TgNTPDase + AMP
    
  • 4a5a, 4kh4 – TgNTPDase (mutant) + AMPPNP
    
  • 4kh5 – TgNTPDase (mutant) + adenosine-imido-diphosphate
    
• NTPDase4
  • 6wg5 – hNTPDase
    

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